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Figure 3. Substrate binding site and heme orientation in CYP154A1. (A) Stereo view of 4-phenylimidazole binding in the active site of CYP154A1. (B) Heme orientation acquired from molecular replacement model CYP154C1. Fragments of Fo-Fc map (red and blue) indicate the requirement of a 180° heme rotation along the axis defined by the 
- and 
-meso carbons, as schematically illustrated in the right part of the figure. Fragments of electron density from 2Fo-Fc composite omit map are contoured at 1.6
(gray), from Fo-Fc map at -3.4 (red), and 3.4 (blue). The colors of the atoms are as follows: oxygen and iron, red; nitrogen, blue; sulfur, yellow; carbon, gray.
